Felix Eckstein and Wolfgang Wirth from PMU wrote a summary of 30 years of quantitative cartilage and bone imaging research, for the special issue of Osteoarthritis and Cartilage journal to celebrate its 30 year anniversary.
30 years of MRI-based cartilage and bone morphometry in knee osteoarthritis” published in the special issue of Osteoarthritis and Cartilage Journal. This exciting journey has taken us from initial “correlation”, i.e. method development with external reference standards for validation to exploring the physiology and pathophysiology of the disease, to qualification studies towards a surrogate endpoint, and finally to interventional “clinical trials”, exploring the structural efficacy of potentially disease modifying OA drugs (DMOADs) on articular tissues.
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